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From Gut to Brain: How Probiotics Can Help With Autism Symptoms

Ready to explore the gutsy side of autism? With over sixty million people affected globally, it's time to shed light on the gut-brain connection and its potential to manage symptoms of this neurodevelopmental diagnosis. From social difficulties to sleep and digestive issues, autism can come with various challenges. But did you know that the health of the gut may hold the key to reducing these symptoms? Join us as we delve into the world of gut microbiota and discover the power of probiotics and prebiotics in unlocking the gut-ASD connection.

A Gutsy Approach to Autism

Autism Spectrum Disorder (ASD) is a unique neurodevelopmental condition that brings a particular set of strengths and challenges. While some may experience difficulty with social interaction and communication, individuals with ASD often have a remarkable ability to focus and excel in specific interests. With a growing prevalence of 1.57% globally and 1.69% in the USA, it's estimated that over 62 million individuals have the gift of ASD (Zhang et al. 2022). The cause of ASD is still largely a mystery, but research suggests a combination of genetic, environmental, epigenetic, and microbiome factors may play a role.

Concurrent symptoms, including gastrointestinal and sleep problems, anxiety, hyperactivity, and attention deficit, are often reported for children with ASD. Gastrointestinal symptoms such as constipation, diarrhea, bloating, pain during bowel movements, and vomiting are also very common. These symptoms have been linked to behaviors like self-injury and aggression.

Sleep disturbances are also prevalent among children with ASD, affecting memory, learning, mood, behavior, immune response, metabolism, and brain development. Common sleep problems include insomnia, increased bedtime resistance, sleep-disordered breathing, early morning awakening, and daytime sleepiness, which have been linked to the severity of behavioral symptoms in children with ASD.

In recent years, research has shown that the gut-brain connection is more critical than previously thought, leading scientists to explore new avenues for managing the challenging symptoms of autism. One of these avenues is using gut microbiota modifiers, such as probiotics and prebiotics. The scientific community has been interested in the relationship between gut bacteria and mental health. The gut-brain axis, regulated by the gut microbiota, influences cognition, social behavior, and emotion through communication with the nervous, immune, and endocrine systems. Research has shown that gut bacteria can significantly impact autism symptoms.

Gut-Check: Are You Familiar With Probiotics and Prebiotics?

Probiotics and prebiotics are the dynamic duos of digestive wellness. Probiotics, live bacteria, and yeasts play the role of gut superheroes, helping to maintain a healthy balance of microorganisms in the digestive system. These tiny but mighty organisms are essential for maintaining overall gut health. They can provide numerous benefits, such as boosting the immune system, improving digestion, and reducing symptoms of certain conditions like irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), anxiety, and depression.

Moreover, probiotics can also be beneficial for children with autism. Studies have shown that children with autism often have imbalances in their gut bacteria, and consuming probiotics may help improve their challenging symptoms. This is because the gut and the brain are closely connected, and a healthy gut can positively impact a child's behavior and mood.

Prebiotics serve as the essential support system for probiotics, providing them with the necessary nourishment to do their job. Prebiotics are non-living food ingredients that are not digested in the small intestine; instead, they pass through to the large intestine, serving as fuel for the beneficial bacteria in the gut.

How Does Probiotic Use Affect the Severity of Autism Symptoms?

Studies have shown a link between altered gut bacteria and autism spectrum disorder. Probiotics, along with the help of prebiotics, help us by improving the gut-brain connection. The gut and brain are like two best friends who love talking to each other. When the gut is healthy, it sends positive messages to the brain, which can help improve mood, behavior, and overall well-being. But an unhealthy gut can send negative messages to the brain, which can contribute to the more difficult symptoms of autism.

Taking probiotics and prebiotics can help keep the gut-brain connection strong by nourishing the good bacteria in the gut. This can help to reduce symptoms such as digestive issues, mood swings, and behavioral challenges. In fact, studies have shown that individuals with autism who take probiotics and prebiotics experience fewer symptoms than those who don't.

What Is Science Saying about the Relationship between Probiotics and Autism?

The evidence to date suggests that probiotics may benefit the gut-brain axis and mental health by improving gut health and affecting the gut microbiome. While we don't have all the answers to our questions yet, the research into the gut-brain connection and the role of probiotics and prebiotics in reducing autism symptoms is promising.

A group of scientists (Zhang et al. 2022) are embarking on a groundbreaking trial to investigate the impact of probiotics on children with ASD. Their previous study found that children with ASD had distinct gut flora compared to those without the condition and that a specific bacterium, Bifidobacterium, was linked to the severity of autism symptoms. This suggests that modulating bacterial composition in the gut may help reduce these symptoms. The upcoming study will examine the effects of probiotic supplementation on autism symptoms to evaluate the therapeutic potential of probiotics for managing symptoms and providing valuable insights for clinical treatment. The results of this study have the potential to deepen our understanding of the relationship between probiotics and autism and could open up new avenues for treating autism symptoms.

In 2020, a study by Xue Ding et al. delved into the gut-brain connection, revealing that children with autism spectrum disorder have a unique gut microbiota profile compared to their neurotypical peers. The findings suggest that the gut's microbial makeup may play a role in shaping brain physiology and behavior and may hold the key to unlocking the mysteries of the gut-ASD connection. One other systematic review by Yang et al. (2020) concluded that prebiotics, probiotics, and other supplements, like vitamin A, could improve the behavioral symptoms of individuals with ASD.

Is the Gut-Brain Connection the Key?

The gut-brain axis is a complex communication system that allows the gut and brain to interact, and the gut microbiome is thought to play an essential role in this interaction. The gut microbiome consists of trillions of microorganisms, including bacteria, fungi, and viruses. It is now understood that it significantly impacts various physiological processes, including the production of neurotransmitters like the mood, appetite, and sleep regulator, serotonin.

As the scientific community continues to explore this connection, we can hope for a brighter future for those living with the challenging symptoms of autism. What we know now is by incorporating probiotics and prebiotics into our diet, we can create a harmonious environment in our gut, leading to optimal digestive wellness. Probiotics can be found in various dietary supplements or in delicious and natural sources such as yogurt, kefir, kimchi, and sauerkraut. Prebiotics can be found in foods like bananas, onions, garlic, and asparagus.

All in all, the growing body of evidence highlights the potential of probiotics and prebiotics in mitigating autism symptoms. The gut-brain connection is a complex network that plays a crucial role in shaping behavior and mood. By nourishing the good bacteria in the gut, individuals with autism may experience improved mood, behavior, and well-being. With the upcoming studies, we hope to gain a further understanding of the relationship between probiotics and autism and pave the way for strain and dosage information. The results of these studies have the potential to bring significant relief to individuals with autism and their families and bring us closer to unlocking the mysteries of the gut-ASD connection.


Ding, Xue, Yiran Xu, Xiaoli Zhang, Lingling Zhang, Guiqin Duan, Chunlan Song, Zhenghua Li, et al. 2020. “Gut Microbiota Changes in Patients with Autism Spectrum Disorders.” Journal of Psychiatric Research 129 (October): 149–59.

Yang, Jiaxin, Xi Fu, Xiaoli Liao, and Yamin Li. 2020. “Effects of Gut Microbial-Based Treatments on Gut Microbiota, Behavioral Symptoms, and Gastrointestinal Symptoms in Children with Autism Spectrum Disorder: A Systematic Review.” Psychiatry Research 293 (November): 113471.

Zhang, Lingling, Yiran Xu, Hongwei Li, Bingbing Li, Guiqin Duan, and Changlian Zhu. 2022. “The Role of Probiotics in Children with Autism Spectrum Disorders: A Study Protocol for a Randomised Controlled Trial.” PLOS ONE 17 (2): e0263109.

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